Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
USERS' SCORE
Good
Based on 21 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Men's Daily Probiotic BlendLactobacillus acidophilusLactobacillus caseiLactobacillus gasseriLactobacillus plantarumLactobacillus paracaseiLactobacillus brevisLactobacillus bulgaricusLactobacillus rhamnosusLactobacillus salivariusLactobacillus fermentumTotal Lacto Cultures (35 Billion CFU)Bifidobacterium lactisBifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (15 Billion CFU)
218 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
365 mg
+
Top Medical Research Studies
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
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Most Useful Reviews
9
Significant improvement
4 people found this helpful
My husband often complained about his stomach due to colon issues, needing the bathroom frequently. Thankfully, he has benefited from this product; his stomach no longer tires from eating. I finished the first box, and the results are excellent. I've ordered another box. His usage involves taking one pill daily on an empty stomach each morning. If this helps, great!
Read More
7.5
Digestive function improved
4 people found this helpful
These probiotics are remarkable! I bought them for my 73-year-old father, who has had multiple colonoscopies that disrupted his microflora. Initially sceptical of dietary supplements, he eventually requested more when he felt drained. I paired the probiotics with psyllium for better digestive support. Remarkably, he noticed a difference within a week! He was reluctant to finish the course, but probiotics truly work, even for serious cases. Highly recommend.
Read More
9
Digestive improvement
3 people found this helpful
Excellent! My husband previously dealt with dysbacteriosis from antibiotics and diet. This complex has worked wonders—no constipation or diarrhoea, and he handles food better. Over a month, he has even shed some extra pounds, and a double chin has disappeared. This product was invaluable during my time in refugee camps in Germany due to the war in Ukraine and led to regularly formed stools. I am extremely satisfied and will repurchase when settled in Germany.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
- All Researches
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
4 people found this helpful
My husband often complained about his stomach due to colon issues, needing the bathroom frequently. Thankfully, he has benefited from this product; his stomach no longer tires from eating. I finished the first box, and the results are excellent. I've ordered another box. His usage involves taking one pill daily on an empty stomach each morning. If this helps, great!
Read More
7.5
Digestive function improved
4 people found this helpful
These probiotics are remarkable! I bought them for my 73-year-old father, who has had multiple colonoscopies that disrupted his microflora. Initially sceptical of dietary supplements, he eventually requested more when he felt drained. I paired the probiotics with psyllium for better digestive support. Remarkably, he noticed a difference within a week! He was reluctant to finish the course, but probiotics truly work, even for serious cases. Highly recommend.
Read More
9
Digestive improvement
3 people found this helpful
Excellent! My husband previously dealt with dysbacteriosis from antibiotics and diet. This complex has worked wonders—no constipation or diarrhoea, and he handles food better. Over a month, he has even shed some extra pounds, and a double chin has disappeared. This product was invaluable during my time in refugee camps in Germany due to the war in Ukraine and led to regularly formed stools. I am extremely satisfied and will repurchase when settled in Germany.
Read More
9
Gut health significance
3 people found this helpful
Hippocrates wrote: "All diseases begin in the intestines." Many now recognise the gut microbiome's importance for immunity and metabolism, notably diabetes and obesity. Dysfunction here impacts brain health, thus monitoring intestinal microflora is crucial. These probiotics work excellently in this regard!
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9
Restored microflora
1 people found this helpful
I absolutely love these probiotics! They are of superb quality and effective. I order these for my husband and use the pink ones from this brand for myself. He consumes them two to three times a year, and they effectively restore intestinal microflora. Purchasing at a discount is lovely, but they are worthwhile at the full price too.
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Frequently Asked Questions
7.5
Digestive function improved
4 people found this helpful
These probiotics are remarkable! I bought them for my 73-year-old father, who has had multiple colonoscopies that disrupted his microflora. Initially sceptical of dietary supplements, he eventually requested more when he felt drained. I paired the probiotics with psyllium for better digestive support. Remarkably, he noticed a difference within a week! He was reluctant to finish the course, but probiotics truly work, even for serious cases. Highly recommend.
9
Effective treatment
1 people found this helpful
Excellent probiotics! The effects were noticeable within just two weeks of starting treatment. After a month, my digestion had normalised, and bowel issues disappeared. To see results, probiotics should be taken in courses — twice a year. They've helped me immensely, and I will reorder!
9
Digestive improvement
3 people found this helpful
Excellent! My husband previously dealt with dysbacteriosis from antibiotics and diet. This complex has worked wonders—no constipation or diarrhoea, and he handles food better. Over a month, he has even shed some extra pounds, and a double chin has disappeared. This product was invaluable during my time in refugee camps in Germany due to the war in Ukraine and led to regularly formed stools. I am extremely satisfied and will repurchase when settled in Germany.
9
Significant improvement
4 people found this helpful
My husband often complained about his stomach due to colon issues, needing the bathroom frequently. Thankfully, he has benefited from this product; his stomach no longer tires from eating. I finished the first box, and the results are excellent. I've ordered another box. His usage involves taking one pill daily on an empty stomach each morning. If this helps, great!
7.5
Symptoms improvement
3 people found this helpful
I ordered this for my husband, who noted a significant improvement in his symptoms of irritable bowel and indigestion. 🤍
7.5
Improved digestion
4 people found this helpful
I ordered this for my husband; the effect is evident when combined with proper nutrition. His gastrointestinal tract has normalised, sleep has improved, and excess weight has begun to diminish.
9
Skin improved
21 people found this helpful
This probiotic is a family favourite, particularly the male version I ordered for my husband to treat a fungal issue. He takes one tablet at night, and his bowel movements have normalised, alongside visible improvements in his skin condition—red fungal spots have vanished. I also periodically use the female version, which is safe during pregnancy. The only downside is the relatively high price; the jar lasts just a month.
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
8
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
We explored the effects of Lactobacillus acidophilus and propionate on Sjögren's syndrome in a mouse model. Our study involved comparing the gut microbiomes of young and older mice while treating them for up to 24 weeks.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
References
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. doi:10.1007/s12017-025-08837-1
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. doi:10.1111/1750-3841.17460
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. doi:10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. doi:10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. doi:10.1016/j.nut.2021.111282
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. doi:10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. doi:10.1007/s00296-020-04558-9
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. doi:10.3390/nu9111166
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. doi:10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. doi:10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. doi:10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. doi:10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. doi:10.1039/d4fo03966a
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. doi:10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. doi:10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. doi:10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. doi:10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. doi:10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. doi:10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. doi:10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. doi:10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. doi:10.1002/jcp.26819
- Piva F, Gervois P, Karrout Y, Sané F, Romond MB. Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023;15. doi:10.3390/nu15234861
- Huo D, Cen C, Chang H, Ou Q, Jiang S, et al. Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis. Commun Biol. 2021;4:1046. doi:10.1038/s42003-021-02587-z
- Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. doi:10.2500/aap.2020.41.200064
- Shi P, Qu H, Nian D, Chen Y, Liu X, et al. Treatment of Guillain-Barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290. doi:10.1016/j.intimp.2018.06.015
- Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation. Br J Nutr. 2013;110:1828. doi:10.1017/S0007114513001098
- Laparra JM, Olivares M, Gallina O, Sanz Y. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS One. 2012;7:e30744. doi:10.1371/journal.pone.0030744
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. doi:10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. doi:10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x
